3MBL
Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP
Summary for 3MBL
| Entry DOI | 10.2210/pdb3mbl/pdb |
| Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | kinase inhibitor, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 37552.95 |
| Authors | Dougan, D.R.,Mol, C.D. (deposition date: 2010-03-25, release date: 2010-07-28, Last modification date: 2024-02-21) |
| Primary citation | Wallace, M.B.,Adams, M.E.,Kanouni, T.,Mol, C.D.,Dougan, D.R.,Feher, V.A.,O'Connell, S.M.,Shi, L.,Halkowycz, P.,Dong, Q. Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors. Bioorg.Med.Chem.Lett., 20:4156-4158, 2010 Cited by PubMed: 20621728DOI: 10.1016/j.bmcl.2010.05.058 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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