3MBL

Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP

3MBL の概要

• エントリーDOI: 10.2210/pdb3mbl/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: kinase inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37552.95

構造登録者

Dougan, D.R.,Mol, C.D. (登録日: 2010-03-25, 公開日: 2010-07-28, 最終更新日: 2024-02-21)

主引用文献

Wallace, M.B.,Adams, M.E.,Kanouni, T.,Mol, C.D.,Dougan, D.R.,Feher, V.A.,O'Connell, S.M.,Shi, L.,Halkowycz, P.,Dong, Q.
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
Bioorg.Med.Chem.Lett., 20:4156-4158, 2010

PubMed Abstract: A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties.

PubMed: 20621728
DOI: 10.1016/j.bmcl.2010.05.058

実験手法

X-RAY DIFFRACTION (2.6 Å)