3MAX

Crystal Structure of Human HDAC2 complexed with an N-(2-aminophenyl)benzamide

Summary for 3MAX

Entry DOI	10.2210/pdb3max/pdb
Descriptor	Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (7 entities in total)
Functional Keywords	class 2, hdac, foot pocket, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q92769
Total number of polymer chains	3
Total formula weight	127895.75
Authors	Skene, R.J.,Jennings, A.J. (deposition date: 2010-03-24, release date: 2010-04-28, Last modification date: 2024-02-21)
Primary citation	Bressi, J.C.,Jennings, A.J.,Skene, R.,Wu, Y.,Melkus, R.,De Jong, R.,O'Connell, S.,Grimshaw, C.E.,Navre, M.,Gangloff, A.R. Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg.Med.Chem.Lett., 20:3142-3145, 2010 Cited by PubMed: 20392638 DOI: 10.1016/j.bmcl.2010.03.091 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation