3M9Q

Drosophila MSL3 chromodomain

3M9Q の概要

• エントリーDOI: 10.2210/pdb3m9q/pdb
• 関連するPDBエントリー: 3M9P
• 分子名称: Protein male-specific lethal-3 (2 entities in total)
• 機能のキーワード: chromodomain, msl3, methyllysine recognition, aromatic cage, msl complex, transcription upregulation, dna binding protein
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• 細胞内の位置: Nucleus : P50536
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24562.10

構造登録者

Kim, D.,Huang, P.,Rastinejad, F.,Khorasanizadeh, S. (登録日: 2010-03-22, 公開日: 2010-07-21, 最終更新日: 2023-09-06)

主引用文献

Kim, D.,Blus, B.J.,Chandra, V.,Huang, P.,Rastinejad, F.,Khorasanizadeh, S.
Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.
Nat.Struct.Mol.Biol., 17:1027-1029, 2010

PubMed Abstract: MSL3 resides in the MSL (male-specific lethal) complex, which upregulates transcription by spreading the histone H4 Lys16 (H4K16) acetyl mark. We discovered a DNA-dependent interaction of MSL3 chromodomain with the H4K20 monomethyl mark. The structure of a ternary complex shows that the DNA minor groove accommodates the histone H4 tail, and monomethyllysine inserts in a four-residue aromatic cage in MSL3. H4K16 acetylation antagonizes MSL3 binding, suggesting that MSL function is regulated by a combination of post-translational modifications.

PubMed: 20657587
DOI: 10.1038/nsmb.1856

実験手法

X-RAY DIFFRACTION (1.29 Å)