3M40

Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide

3M40 の概要

• エントリーDOI: 10.2210/pdb3m40/pdb
• 関連するPDBエントリー: 3M2N 3M3X 3M5E 3MHI 3MHL 3MHM 3MHO
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-[(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide, ... (5 entities in total)
• 機能のキーワード: drug design, carbonic anhydrase, sulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29762.32

構造登録者

Grazulis, S.,Manakova, E.,Golovenko, D. (登録日: 2010-03-10, 公開日: 2010-10-20, 最終更新日: 2023-11-01)

• 主引用文献: Sudzius, J.,Baranauskiene, L.,Golovenko, D.,Matuliene, J.,Michailoviene, V.,Torresan, J.,Jachno, J.,Sukackaite, R.,Manakova, E.,Grazulis, S.,Tumkevicius, S.,Matulis, D.; 4-[N-(Substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII; Bioorg.Med.Chem., 18:7413-7421, 2010; PubMed: 20889345; DOI: 10.1016/j.bmc.2010.09.011

実験手法

X-RAY DIFFRACTION (1.6 Å)