3M2N

Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide

3M2N の概要

• エントリーDOI: 10.2210/pdb3m2n/pdb
• 関連するPDBエントリー: 3M3X 3M40 3M5E 3MHI 3MHL 3MHM 3MHO
• 分子名称: Carbonic anhydrase 2, 4-{2-[(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide, ZINC ION, ... (6 entities in total)
• 機能のキーワード: drug design, carbonic anhydrase, sulfonamide, lyase, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30031.68

構造登録者

Grazulis, S.,Manakova, E.,Golovenko, D. (登録日: 2010-03-08, 公開日: 2011-02-16, 最終更新日: 2023-11-01)

• 主引用文献: Capkauskaite, E.,Zubriene, A.,Baranauskiene, L.,Tamulaitiene, G.,Manakova, E.,Kairys, V.,Grazulis, S.,Tumkevicius, S.,Matulis, D.; Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases.; Eur.J.Med.Chem., 51:259-270, 2012; PubMed: 22440859; DOI: 10.1016/j.ejmech.2012.02.050

実験手法

X-RAY DIFFRACTION (1.65 Å)