3LV3
Crystal structure of HLA-B*2705 complexed with a peptide derived from the human voltage-dependent calcium channel alpha1 subunit (residues 513-521)
3LV3 の概要
エントリーDOI | 10.2210/pdb3lv3/pdb |
関連するPDBエントリー | 1OF2 1OGT 1UXS 1UXW 2A83 3CZF |
分子名称 | HLA class I histocompatibility antigen, B-27 alpha chain, Beta-2-microglobulin, 9-meric peptide from Voltage-dependent L-type calcium channel subunit alpha-1D, ... (5 entities in total) |
機能のキーワード | immune system, mhc (major histocompatibility complex), hla-b*2705, disulfide bond, glycoprotein, immune response, membrane, mhc i, transmembrane, amyloid, amyloidosis, disease mutation, glycation, immunoglobulin domain, secreted, calcium channel, voltage-gated channel |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Membrane; Single-pass type I membrane protein: P03989 Secreted: P61769 Membrane; Multi-pass membrane protein: Q01668 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 45461.38 |
構造登録者 | Loll, B.,Rueckert, C.,Saenger, W.,Uchanska-Ziegler, B.,Ziegler, A. (登録日: 2010-02-19, 公開日: 2010-11-24, 最終更新日: 2023-11-01) |
主引用文献 | Loll, B.,Ruckert, C.,Hee, C.S.,Saenger, W.,Uchanska-Ziegler, B.,Ziegler, A. Loss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptide. Protein Sci., 20:278-290, 2011 Cited by PubMed: 21280120DOI: 10.1002/pro.559 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.94 Å) |
構造検証レポート
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