3LV3

Crystal structure of HLA-B*2705 complexed with a peptide derived from the human voltage-dependent calcium channel alpha1 subunit (residues 513-521)

3LV3 の概要

• エントリーDOI: 10.2210/pdb3lv3/pdb
• 関連するPDBエントリー: 1OF2 1OGT 1UXS 1UXW 2A83 3CZF
• 分子名称: HLA class I histocompatibility antigen, B-27 alpha chain, Beta-2-microglobulin, 9-meric peptide from Voltage-dependent L-type calcium channel subunit alpha-1D, ... (5 entities in total)
• 機能のキーワード: immune system, mhc (major histocompatibility complex), hla-b*2705, disulfide bond, glycoprotein, immune response, membrane, mhc i, transmembrane, amyloid, amyloidosis, disease mutation, glycation, immunoglobulin domain, secreted, calcium channel, voltage-gated channel
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P03989; Secreted: P61769; Membrane; Multi-pass membrane protein: Q01668
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45461.38

構造登録者

Loll, B.,Rueckert, C.,Saenger, W.,Uchanska-Ziegler, B.,Ziegler, A. (登録日: 2010-02-19, 公開日: 2010-11-24, 最終更新日: 2023-11-01)

• 主引用文献: Loll, B.,Ruckert, C.,Hee, C.S.,Saenger, W.,Uchanska-Ziegler, B.,Ziegler, A.; Loss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptide.; Protein Sci., 20:278-290, 2011; PubMed: 21280120; DOI: 10.1002/pro.559

実験手法

X-RAY DIFFRACTION (1.94 Å)