3LU9

Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1

3LU9 の概要

• エントリーDOI: 10.2210/pdb3lu9/pdb
• 関連するPDBエントリー: 1SHH
• 分子名称: Prothrombin, Proteinase-activated receptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: serine protease, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, pharmaceutical, polymorphism, protease, secreted, zymogen, cell membrane, g-protein coupled receptor, membrane, phosphoprotein, receptor, transducer, transmembrane
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 76841.28

構造登録者

Gandhi, P.S.,Chen, Z.,Di Cera, E. (登録日: 2010-02-17, 公開日: 2010-03-16, 最終更新日: 2023-09-06)

• 主引用文献: Gandhi, P.S.,Chen, Z.,Di Cera, E.; Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1.; J.Biol.Chem., 285:15393-15398, 2010; PubMed: 20236938; DOI: 10.1074/jbc.M110.115337

実験手法

X-RAY DIFFRACTION (1.8 Å)