3LQS

Complex Structure of D-Amino Acid Aminotransferase and 4-amino-4,5-dihydro-thiophenecarboxylic acid (ADTA)

Summary for 3LQS

• Entry DOI: 10.2210/pdb3lqs/pdb
• Related: 3DAA
• Descriptor: D-alanine aminotransferase, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ACETIC ACID, ... (4 entities in total)
• Functional Keywords: plp aminotransferase, mechanism-based inhibitor, stereo-specificity, r-adta, aminotransferase, pyridoxal phosphate, transferase
• Biological source: Bacillus sp.
• Total number of polymer chains: 2
• Total formula weight: 64929.88

Authors

Lepore, B.W.,Liu, D.,Peng, Y.,Fu, M.,Yasuda, C.,Manning, J.M.,Silverman, R.B.,Ringe, D. (deposition date: 2010-02-10, release date: 2010-03-16, Last modification date: 2024-02-21)

• Primary citation: Lepore, B.W.,Liu, D.,Peng, Y.,Fu, M.,Yasuda, C.,Manning, J.M.,Silverman, R.B.,Ringe, D.; Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid.; Biochemistry, 49:3138-3147, 2010; PubMed: 20192272; DOI: 10.1021/bi902052x

Experimental method

X-RAY DIFFRACTION (1.9 Å)