3LQM

Structure of the IL-10R2 Common Chain

3LQM の概要

• エントリーDOI: 10.2210/pdb3lqm/pdb
• 分子名称: Interleukin-10 receptor subunit beta, SULFATE ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: il-10r2, receptor, common chain, cytokine, il-10, il-22, il-26, il-28, il-29, disulfide bond, glycoprotein, membrane, phosphoprotein, polymorphism, transmembrane, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48219.45

構造登録者

Yoon, S.I.,Walter, M.R. (登録日: 2010-02-09, 公開日: 2010-05-26, 最終更新日: 2024-11-27)

主引用文献

Yoon, S.I.,Jones, B.C.,Logsdon, N.J.,Harris, B.D.,Deshpande, A.,Radaeva, S.,Halloran, B.A.,Gao, B.,Walter, M.R.
Structure and mechanism of receptor sharing by the IL-10R2 common chain.
Structure, 18:638-648, 2010

PubMed Abstract: IL-10R2 is a shared cell surface receptor required for the activation of five class 2 cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) that play critical roles in host defense. To define the molecular mechanisms that regulate its promiscuous binding, we have determined the crystal structure of the IL-10R2 ectodomain at 2.14 A resolution. IL-10R2 residues required for binding were identified by alanine scanning and used to derive computational models of IL-10/IL-10R1/IL-10R2 and IL-22/IL-22R1/IL-10R2 ternary complexes. The models reveal a conserved binding epitope that is surrounded by two clefts that accommodate the structural and chemical diversity of the cytokines. These results provide a structural framework for interpreting IL-10R2 single nucleotide polymorphisms associated with human disease.

PubMed: 20462497
DOI: 10.1016/j.str.2010.02.009

実験手法

X-RAY DIFFRACTION (2.14 Å)