3LQ5

Structure of CDK9/CyclinT in complex with S-CR8

Summary for 3LQ5

• Entry DOI: 10.2210/pdb3lq5/pdb
• Related: 3BLH 3BLQ 3BLR
• Descriptor: Cell division protein kinase 9, Cyclin-T1, (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, ... (4 entities in total)
• Functional Keywords: transcriptional cdk-cyclin complex, phosphorylated, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transcription regulation, transferase, cell cycle, cell division, host-virus interaction, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P50750 O60563
• Total number of polymer chains: 2
• Total formula weight: 68605.04

Authors

Hole, A.J.,Endicott, J.A.,Baumli, S. (deposition date: 2010-02-08, release date: 2011-01-19, Last modification date: 2023-11-01)

• Primary citation: Bettayeb, K.,Baunbak, D.,Delehouze, C.,Loaec, N.,Hole, A.J.,Baumli, S.,Endicott, J.A.,Douc-Rasy, S.,Benard, J.,Oumata, N.,Galons, H.,Meijer, L.; CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells; Genes Cancer, 1:369-380, 2010; PubMed: 21779453; DOI: 10.1177/1947601910369817

Experimental method

X-RAY DIFFRACTION (3 Å)