3LQ5

Structure of CDK9/CyclinT in complex with S-CR8

3LQ5 の概要

• エントリーDOI: 10.2210/pdb3lq5/pdb
• 関連するPDBエントリー: 3BLH 3BLQ 3BLR
• 分子名称: Cell division protein kinase 9, Cyclin-T1, (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, ... (4 entities in total)
• 機能のキーワード: transcriptional cdk-cyclin complex, phosphorylated, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transcription regulation, transferase, cell cycle, cell division, host-virus interaction, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P50750 O60563
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68605.04

構造登録者

Hole, A.J.,Endicott, J.A.,Baumli, S. (登録日: 2010-02-08, 公開日: 2011-01-19, 最終更新日: 2023-11-01)

• 主引用文献: Bettayeb, K.,Baunbak, D.,Delehouze, C.,Loaec, N.,Hole, A.J.,Baumli, S.,Endicott, J.A.,Douc-Rasy, S.,Benard, J.,Oumata, N.,Galons, H.,Meijer, L.; CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells; Genes Cancer, 1:369-380, 2010; PubMed: 21779453; DOI: 10.1177/1947601910369817

実験手法

X-RAY DIFFRACTION (3 Å)