3LPZ
Crystal structure of C. therm. Get4
Summary for 3LPZ
| Entry DOI | 10.2210/pdb3lpz/pdb |
| Related | 2WPV 3IQW 3IQX 3LKU |
| Descriptor | Uncharacterized protein (2 entities in total) |
| Functional Keywords | protein targeting, tail-anchored protein biogenesis, get pathway, get5 binding, protein transport |
| Biological source | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) |
| Total number of polymer chains | 1 |
| Total formula weight | 37270.34 |
| Authors | Bozkurt, G.,Wild, K.,Sinning, I. (deposition date: 2010-02-08, release date: 2010-03-16, Last modification date: 2024-02-21) |
| Primary citation | Bozkurt, G.,Wild, K.,Amlacher, S.,Hurt, E.,Dobberstein, B.,Sinning, I. The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis. Febs Lett., 584:1509-1514, 2010 Cited by PubMed Abstract: Tail-anchored proteins play important roles in protein translocation, membrane fusion and apoptosis. They are targeted to the endoplasmic reticulum membrane via the guided-entry of tail-anchored proteins (Get) pathway. We present the 2A crystal structure of Get4 which participates in early steps of the Get pathway. The structure shows an alpha-solenoid fold with particular deviations from the regular pairwise arrangement of alpha-helices. A conserved hydrophobic groove accommodates the flexible C-terminal region in trans. The structural organization of the Get4 helical hairpin motifs provides a scaffold for protein-protein interactions in the Get pathway. PubMed: 20206626DOI: 10.1016/j.febslet.2010.02.070 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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