3LPZ

Crystal structure of C. therm. Get4

3LPZ の概要

• エントリーDOI: 10.2210/pdb3lpz/pdb
• 関連するPDBエントリー: 2WPV 3IQW 3IQX 3LKU
• 分子名称: Uncharacterized protein (2 entities in total)
• 機能のキーワード: protein targeting, tail-anchored protein biogenesis, get pathway, get5 binding, protein transport
• 由来する生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37270.34

構造登録者

Bozkurt, G.,Wild, K.,Sinning, I. (登録日: 2010-02-08, 公開日: 2010-03-16, 最終更新日: 2024-02-21)

主引用文献

Bozkurt, G.,Wild, K.,Amlacher, S.,Hurt, E.,Dobberstein, B.,Sinning, I.
The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis.
Febs Lett., 584:1509-1514, 2010

PubMed Abstract: Tail-anchored proteins play important roles in protein translocation, membrane fusion and apoptosis. They are targeted to the endoplasmic reticulum membrane via the guided-entry of tail-anchored proteins (Get) pathway. We present the 2A crystal structure of Get4 which participates in early steps of the Get pathway. The structure shows an alpha-solenoid fold with particular deviations from the regular pairwise arrangement of alpha-helices. A conserved hydrophobic groove accommodates the flexible C-terminal region in trans. The structural organization of the Get4 helical hairpin motifs provides a scaffold for protein-protein interactions in the Get pathway.

PubMed: 20206626
DOI: 10.1016/j.febslet.2010.02.070

実験手法

X-RAY DIFFRACTION (1.98 Å)