3LPJ
Structure of BACE Bound to SCH743641
Summary for 3LPJ
Entry DOI | 10.2210/pdb3lpj/pdb |
Related | 3LPI 3LPK |
Descriptor | Beta-secretase 1, L(+)-TARTARIC ACID, N'-[(1S,2S)-2-[(2R)-4-benzylpiperazin-2-yl]-1-(3,5-difluorobenzyl)-2-hydroxyethyl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide, ... (4 entities in total) |
Functional Keywords | alzheimer's, aspartyl protease, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 2 |
Total formula weight | 101954.65 |
Authors | Strickland, C.,Cumming, J. (deposition date: 2010-02-05, release date: 2010-04-14, Last modification date: 2017-11-01) |
Primary citation | Cumming, J.,Babu, S.,Huang, Y.,Carrol, C.,Chen, X.,Favreau, L.,Greenlee, W.,Guo, T.,Kennedy, M.,Kuvelkar, R.,Le, T.,Li, G.,McHugh, N.,Orth, P.,Ozgur, L.,Parker, E.,Saionz, K.,Stamford, A.,Strickland, C.,Tadesse, D.,Voigt, J.,Zhang, L.,Zhang, Q. Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20:2837-2842, 2010 Cited by PubMed: 20347593DOI: 10.1016/j.bmcl.2010.03.050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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