3LN0
Structure of compound 5c-S bound at the active site of COX-2
3LN0 の概要
エントリーDOI | 10.2210/pdb3ln0/pdb |
関連するBIRD辞書のPRD_ID | PRD_900017 |
分子名称 | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total) |
機能のキーワード | cox2, cox-2, pgh2s-2, cyclooxygenase-2, dioxygenase, disulfide bond, endoplasmic reticulum, fatty acid biosynthesis, glycoprotein, heme, iron, lipid synthesis, membrane, metal-binding, microsome, oxidoreductase, peroxidase, phosphoprotein, prostaglandin biosynthesis |
由来する生物種 | Mus musculus (mouse) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 277913.80 |
構造登録者 | Kiefer, J.R.,Kurumbail, R.G.,Stallings, W.C.,Pawlitz, J.L. (登録日: 2010-02-01, 公開日: 2010-10-27, 最終更新日: 2020-07-29) |
主引用文献 | Wang, J.L.,Limburg, D.,Graneto, M.J.,Springer, J.,Hamper, J.R.,Liao, S.,Pawlitz, J.L.,Kurumbail, R.G.,Maziasz, T.,Talley, J.J.,Kiefer, J.R.,Carter, J. The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life. Bioorg.Med.Chem.Lett., 20:7159-7163, 2010 Cited by PubMed: 20709553DOI: 10.1016/j.bmcl.2010.07.054 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
構造検証レポート
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