3LM5

Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin

Summary for 3LM5

Entry DOI	10.2210/pdb3lm5/pdb
Related	3EHA
Descriptor	Serine/threonine-protein kinase 17B, 3,5,7,3',4'-PENTAHYDROXYFLAVONE (3 entities in total)
Functional Keywords	stk17b, serine/threonine kinase 17b, drak2, dap kinase related apoptosis-inducing protein kinase 2, death-associated protein kinase-related 2, structural genomics, structural genomics consortium, sgc, apoptosis, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37629.32
Authors	Ugochukwu, E.,Soundararajan, M.,Rellos, P.,Fedorov, O.,Phillips, C.,Wang, J.,Hapka, E.,Filippakopoulos, P.,Chaikuad, A.,Pike, A.C.W.,Carpenter, L.,Vollmar, M.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-01-29, release date: 2010-03-16, Last modification date: 2023-09-06)
Primary citation	Picado, A.,Chaikuad, A.,Wells, C.I.,Shrestha, S.,Zuercher, W.J.,Pickett, J.E.,Kwarcinski, F.E.,Sinha, P.,de Silva, C.S.,Zutshi, R.,Liu, S.,Kannan, N.,Knapp, S.,Drewry, D.H.,Willson, T.M. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63:14626-14646, 2020 Cited by PubMed: 33215924 DOI: 10.1021/acs.jmedchem.0c01174 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation