3LL1

Monomeric Griffithsin with a Single Gly-Ser Insertion and Mutations to Remove Residual Self-Association

3LL1 の概要

• エントリーDOI: 10.2210/pdb3ll1/pdb
• 関連するPDBエントリー: 2gty 2guc 2gud 2gue 2gux 2hyq 2hyr 2nu5 2nuo 3LKY 3LL0 3LL2
• 分子名称: Griffithsin, CHLORIDE ION (3 entities in total)
• 機能のキーワード: lectin, sugar-binding, anti-hiv, high mannose, man9, gp120, gp41, jacalin-related, mannose-binding, sugar binding protein
• 由来する生物種: Griffithsia (Red alga)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12663.08

構造登録者

Moulaei, T.,Wlodawer, A. (登録日: 2010-01-28, 公開日: 2010-10-06, 最終更新日: 2023-09-06)

• 主引用文献: Moulaei, T.,Shenoy, S.R.,Giomarelli, B.,Thomas, C.,McMahon, J.B.,Dauter, Z.,O'Keefe, B.R.,Wlodawer, A.; Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity.; Structure, 18:1104-1115, 2010; PubMed: 20826337; DOI: 10.1016/j.str.2010.05.016

実験手法

X-RAY DIFFRACTION (0.97 Å)