3LFQ

Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor

3LFQ の概要

• エントリーDOI: 10.2210/pdb3lfq/pdb
• 関連するPDBエントリー: 3FLN 3FLS
• 分子名称: Cell division protein kinase 2, N-(6,7-difluoro-5-phenyl-1H-indazol-3-yl)butanamide (3 entities in total)
• 機能のキーワード: protein kinase fold, acetylation, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34291.81

構造登録者

Dreyer, M.K.,Wendt, K.U.,Schimanski-Breves, S.,Loenze, P. (登録日: 2010-01-18, 公開日: 2010-03-02, 最終更新日: 2024-02-21)

• 主引用文献: Lesuisse, D.,Dutruc-Rosset, G.,Tiraboschi, G.,Dreyer, M.K.,Maignan, S.,Chevalier, A.,Halley, F.,Bertrand, P.,Burgevin, M.C.,Quarteronet, D.,Rooney, T.; Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.; Bioorg.Med.Chem.Lett., 20:1985-1989, 2010; PubMed: 20167481; DOI: 10.1016/j.bmcl.2010.01.114

実験手法

X-RAY DIFFRACTION (2.03 Å)