3LFN

Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor

Summary for 3LFN

Entry DOI	10.2210/pdb3lfn/pdb
Related	3FLS 3LFQ
Descriptor	Cell division protein kinase 2, N-[6-(4-hydroxyphenyl)-5-phenyl-1H-indazol-3-yl]butanamide (3 entities in total)
Functional Keywords	protein kinase fold, acetylation, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34347.92
Authors	Dreyer, M.K.,Wendt, K.U.,Schimanski-Breves, S.,Loenze, P. (deposition date: 2010-01-18, release date: 2010-03-02, Last modification date: 2024-02-21)
Primary citation	Lesuisse, D.,Dutruc-Rosset, G.,Tiraboschi, G.,Dreyer, M.K.,Maignan, S.,Chevalier, A.,Halley, F.,Bertrand, P.,Burgevin, M.C.,Quarteronet, D.,Rooney, T. Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20:1985-1989, 2010 Cited by PubMed Abstract: From an HTS hit, a series of potent and selective inhibitors of GSK3beta have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2. PubMed: 20167481 DOI: 10.1016/j.bmcl.2010.01.114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation