3LFA

Human p38 MAP Kinase in Complex with Dasatinib

3LFA の概要

• エントリーDOI: 10.2210/pdb3lfa/pdb
• 関連するPDBエントリー: 3LFB 3LFC 3LFD 3LFE 3LFF
• 分子名称: Mitogen-activated protein kinase 14, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: thiazole-urea, dfg-out, sar, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42049.43

構造登録者

Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (登録日: 2010-01-16, 公開日: 2011-04-20, 最終更新日: 2023-09-06)

• 主引用文献: Getlik, M.,Gruetter, C.,Simard, J.R.,Van Otterlo, W.,Robubi, A.,Aust, B.,Rauh, D.; Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha; To be Published,

実験手法

X-RAY DIFFRACTION (2.1 Å)