3LEX

2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 11F10 in complex with HIV-1 GP41

Summary for 3LEX

Entry DOI	10.2210/pdb3lex/pdb
Related	1TJI 3LES 3LEV 3LEY
Descriptor	11f10 Antibody Heavy Chain, 11f10 Antibody Light Chain, Envelope glycoprotein gp41, ... (4 entities in total)
Functional Keywords	hiv-1, gp-41, monoclonal antibody, 2f5, scaffold, epitope, transplant, graft, re-elcitation, envelope protein, immune system, vaccine design
Biological source	Mus musculus (mouse) More
Total number of polymer chains	6
Total formula weight	98333.76
Authors	Ofek, G.,Guenaga, F.J.,Schief, W.R.,Skinner, J.,Baker, D.,Wyatt, R.,Kwong, P.D. (deposition date: 2010-01-15, release date: 2010-09-29, Last modification date: 2023-09-06)
Primary citation	Ofek, G.,Guenaga, F.J.,Schief, W.R.,Skinner, J.,Baker, D.,Wyatt, R.,Kwong, P.D. Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107:17880-17887, 2010 Cited by PubMed: 20876137 DOI: 10.1073/pnas.1004728107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation