3L6P

Crystal Structure of Dengue Virus 1 NS2B/NS3 protease

Summary for 3L6P

• Entry DOI: 10.2210/pdb3l6p/pdb
• Related: 3LKW
• Descriptor: fusion protein of nonstructural protein 2B and nonstructural protein 3, NICKEL (II) ION, CADMIUM ION, ... (5 entities in total)
• Functional Keywords: viral protease, serine protease, ns3 protease, ns2b cofactor, viral protein, hydrolase
• Biological source: Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1); More
• Cellular location: Protein C: Virion. Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein. Envelope protein E: Virion membrane ; Multi-pass membrane protein. Non-structural protein 1: Secreted . Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P17763
• Total number of polymer chains: 1
• Total formula weight: 25447.43

Authors

Chandramouli, S.,Joseph, J.S.,Daudenarde, S.,Gatchalian, J.,Cornillez-Ty, C.,Kuhn, P. (deposition date: 2009-12-23, release date: 2010-03-02, Last modification date: 2023-09-06)

• Primary citation: Chandramouli, S.,Joseph, J.S.,Daudenarde, S.,Gatchalian, J.,Cornillez-Ty, C.,Kuhn, P.; Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family.; J.Virol., 84:3059-3067, 2010; PubMed: 20042502; DOI: 10.1128/JVI.02044-09

Experimental method

X-RAY DIFFRACTION (2.2 Å)