3L6P

Crystal Structure of Dengue Virus 1 NS2B/NS3 protease

3L6P の概要

• エントリーDOI: 10.2210/pdb3l6p/pdb
• 関連するPDBエントリー: 3LKW
• 分子名称: fusion protein of nonstructural protein 2B and nonstructural protein 3, NICKEL (II) ION, CADMIUM ION, ... (5 entities in total)
• 機能のキーワード: viral protease, serine protease, ns3 protease, ns2b cofactor, viral protein, hydrolase
• 由来する生物種: Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1); 詳細
• 細胞内の位置: Protein C: Virion. Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein. Envelope protein E: Virion membrane ; Multi-pass membrane protein. Non-structural protein 1: Secreted . Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P17763
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25447.43

構造登録者

Chandramouli, S.,Joseph, J.S.,Daudenarde, S.,Gatchalian, J.,Cornillez-Ty, C.,Kuhn, P. (登録日: 2009-12-23, 公開日: 2010-03-02, 最終更新日: 2023-09-06)

• 主引用文献: Chandramouli, S.,Joseph, J.S.,Daudenarde, S.,Gatchalian, J.,Cornillez-Ty, C.,Kuhn, P.; Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family.; J.Virol., 84:3059-3067, 2010; PubMed: 20042502; DOI: 10.1128/JVI.02044-09

実験手法

X-RAY DIFFRACTION (2.2 Å)