3L6H

Crystal structure of lactococcal OpuAC in its closed-liganded conformation complexed with glycine betaine

3L6H の概要

• エントリーDOI: 10.2210/pdb3l6h/pdb
• 関連するPDBエントリー: 3L6G
• 分子名称: Betaine ABC transporter permease and substrate binding protein, TRIMETHYL GLYCINE, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: glycine betaine binding, substrate binding domain, venus fly-trap, cell membrane, membrane, transmembrane, transport, glycine betaine-binding protein
• 由来する生物種: Lactococcus lactis (Streptococcus lactis)
• 細胞内の位置: Membrane; Multi-pass membrane protein (By similarity): Q7DAU8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28736.47

構造登録者

Berntsson, R.P.A.,Wolters, J.C.,Gul, N.,Karasawa, A.,Thunnissen, A.M.W.H.,Slotboom, D.J.,Poolman, B. (登録日: 2009-12-23, 公開日: 2010-05-19, 最終更新日: 2023-11-15)

主引用文献

Wolters, J.C.,Berntsson, R.P.,Gul, N.,Karasawa, A.,Thunnissen, A.M.,Slotboom, D.J.,Poolman, B.
Ligand binding and crystal structures of the substrate-binding domain of the ABC transporter OpuA.
Plos One, 5:e10361-e10361, 2010

PubMed Abstract: The ABC transporter OpuA from Lactococcus lactis transports glycine betaine upon activation by threshold values of ionic strength. In this study, the ligand binding characteristics of purified OpuA in a detergent-solubilized state and of its substrate-binding domain produced as soluble protein (OpuAC) was characterized.

PubMed: 20454456
DOI: 10.1371/journal.pone.0010361

実験手法

X-RAY DIFFRACTION (2.3 Å)