3L6F

Structure of MHC class II molecule HLA-DR1 complexed with phosphopeptide MART-1

3L6F の概要

• エントリーDOI: 10.2210/pdb3l6f/pdb
• 分子名称: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, Melanoma antigen recognized by T-cells 1, ... (4 entities in total)
• 機能のキーワード: mhc class ii, hla-dr1, phosphopeptide, disulfide bond, glycoprotein, immune response, membrane, mhc ii, transmembrane, endoplasmic reticulum, golgi apparatus, immune system-peptide binding protein complex, immune system/peptide binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45267.73

構造登録者

Li, Y.,Mariuzza, R.A. (登録日: 2009-12-23, 公開日: 2010-05-12, 最終更新日: 2023-09-06)

• 主引用文献: Li, Y.,Depontieu, F.R.,Sidney, J.,Salay, T.M.,Engelhard, V.H.,Hunt, D.F.,Sette, A.,Topalian, S.L.,Mariuzza, R.A.; Structural Basis for the Presentation of Tumor-Associated MHC Class II-Restricted Phosphopeptides to CD4(+) T Cells.; J.Mol.Biol., 399:596-603, 2010; PubMed: 20417641; DOI: 10.1016/j.jmb.2010.04.037

実験手法

X-RAY DIFFRACTION (2.1 Å)