3L5D

Structure of BACE Bound to SCH723873

3L5D の概要

• エントリーDOI: 10.2210/pdb3l5d/pdb
• 関連するPDBエントリー: 3L58 3L59 3L5B 3L5C 3L5E 3L5F
• 分子名称: Beta-secretase 1, D(-)-TARTARIC ACID, 1-butyl-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea, ... (4 entities in total)
• 機能のキーワード: bace1, alzheimers, alternative splicing, aspartyl protease, disulfide bond, endoplasmic reticulum, endosome, glycoprotein, golgi apparatus, hydrolase, membrane, polymorphism, protease, transmembrane, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P56817
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 93725.15

構造登録者

Strickland, C.,Zhu, Z. (登録日: 2009-12-21, 公開日: 2010-02-16, 最終更新日: 2017-11-01)

• 主引用文献: Zhu, Z.,Sun, Z.Y.,Ye, Y.,Voigt, J.,Strickland, C.,Smith, E.M.,Cumming, J.,Wang, L.,Wong, J.,Wang, Y.S.,Wyss, D.F.,Chen, X.,Kuvelkar, R.,Kennedy, M.E.,Favreau, L.,Parker, E.,McKittrick, B.A.,Stamford, A.,Czarniecki, M.,Greenlee, W.,Hunter, J.C.; Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation; J.Med.Chem., 53:951-965, 2010; PubMed: 20043696; DOI: 10.1021/jm901408p

実験手法

X-RAY DIFFRACTION (1.75 Å)