3L59

Structure of BACE Bound to SCH710413

Summary for 3L59

• Entry DOI: 10.2210/pdb3l59/pdb
• Related: 3L58 3L5B 3L5C 3L5D 3L5E 3L5F
• Descriptor: Beta-secretase 1, D(-)-TARTARIC ACID, (2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidazolidin-4-one, ... (4 entities in total)
• Functional Keywords: bace1, alzheimers, alternative splicing, aspartyl protease, disulfide bond, endoplasmic reticulum, endosome, glycoprotein, golgi apparatus, hydrolase, membrane, polymorphism, protease, transmembrane, zymogen
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P56817
• Total number of polymer chains: 2
• Total formula weight: 93201.82

Authors

Strickland, C.,Zhu, Z. (deposition date: 2009-12-21, release date: 2010-02-16, Last modification date: 2018-01-24)

• Primary citation: Zhu, Z.,Sun, Z.Y.,Ye, Y.,Voigt, J.,Strickland, C.,Smith, E.M.,Cumming, J.,Wang, L.,Wong, J.,Wang, Y.S.,Wyss, D.F.,Chen, X.,Kuvelkar, R.,Kennedy, M.E.,Favreau, L.,Parker, E.,McKittrick, B.A.,Stamford, A.,Czarniecki, M.,Greenlee, W.,Hunter, J.C.; Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation; J.Med.Chem., 53:951-965, 2010; PubMed: 20043696; DOI: 10.1021/jm901408p

Experimental method

X-RAY DIFFRACTION (2 Å)