3L59
Structure of BACE Bound to SCH710413
Summary for 3L59
Entry DOI | 10.2210/pdb3l59/pdb |
Related | 3L58 3L5B 3L5C 3L5D 3L5E 3L5F |
Descriptor | Beta-secretase 1, D(-)-TARTARIC ACID, (2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidazolidin-4-one, ... (4 entities in total) |
Functional Keywords | bace1, alzheimers, alternative splicing, aspartyl protease, disulfide bond, endoplasmic reticulum, endosome, glycoprotein, golgi apparatus, hydrolase, membrane, polymorphism, protease, transmembrane, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 2 |
Total formula weight | 93201.82 |
Authors | Strickland, C.,Zhu, Z. (deposition date: 2009-12-21, release date: 2010-02-16, Last modification date: 2018-01-24) |
Primary citation | Zhu, Z.,Sun, Z.Y.,Ye, Y.,Voigt, J.,Strickland, C.,Smith, E.M.,Cumming, J.,Wang, L.,Wong, J.,Wang, Y.S.,Wyss, D.F.,Chen, X.,Kuvelkar, R.,Kennedy, M.E.,Favreau, L.,Parker, E.,McKittrick, B.A.,Stamford, A.,Czarniecki, M.,Greenlee, W.,Hunter, J.C. Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53:951-965, 2010 Cited by PubMed: 20043696DOI: 10.1021/jm901408p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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