3L4T

Crystal complex of N-terminal Human Maltase-Glucoamylase with BJ2661

3L4T の概要

• エントリーDOI: 10.2210/pdb3l4t/pdb
• 関連するPDBエントリー: 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z
• 分子名称: Maltase-glucoamylase, intestinal, (1R,2S)-1-[(1S)-1,2-dihydroxyethyl]-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-2-hydroxypropyl sulfate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: glycoside hydrolase family 31, cell membrane, disulfide bond, glycoprotein, glycosidase, hydrolase, membrane, multifunctional enzyme, polymorphism, signal-anchor, sulfation, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Apical cell membrane; Single-pass type II membrane protein: O43451
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 100083.55

構造登録者

Sim, L.,Rose, D.R. (登録日: 2009-12-21, 公開日: 2010-02-09, 最終更新日: 2020-07-29)

• 主引用文献: Sim, L.,Jayakanthan, K.,Mohan, S.,Nasi, R.,Johnston, B.D.,Pinto, B.M.,Rose, D.R.; New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.; Biochemistry, 49:443-451, 2010; PubMed: 20039683; DOI: 10.1021/bi9016457

実験手法

X-RAY DIFFRACTION (1.9 Å)