3L3U

Crystal structure of the HIV-1 integrase core domain to 1.4A

Summary for 3L3U

• Entry DOI: 10.2210/pdb3l3u/pdb
• Related: 1bl3 1ex4 3L3V
• Descriptor: POL polyprotein, SULFATE ION (3 entities in total)
• Functional Keywords: dna integration, aids, integrase, endonuclease, polynucleotidyl transferase, dna binding, viral protein
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 35892.54

Authors

Wielens, J.,Chalmers, D.K.,Scanlon, M.J.,Parker, M.W. (deposition date: 2009-12-17, release date: 2010-03-31, Last modification date: 2023-11-01)

Primary citation

Wielens, J.,Headey, S.J.,Jeevarajah, D.,Rhodes, D.I.,Deadman, J.,Chalmers, D.K.,Scanlon, M.J.,Parker, M.W.
Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site.
Febs Lett., 584:1455-1462, 2010

PubMed Abstract: HIV integrase (IN) is an essential enzyme in HIV replication and an important target for drug design. IN has been shown to interact with a number of cellular and viral proteins during the integration process. Disruption of these important interactions could provide a mechanism for allosteric inhibition of IN. We present the highest resolution crystal structure of the IN core domain to date. We also present a crystal structure of the IN core domain in complex with sucrose which is bound at the dimer interface in a region that has previously been reported to bind integrase inhibitors.

PubMed: 20227411
DOI: 10.1016/j.febslet.2010.03.016

Experimental method

X-RAY DIFFRACTION (1.4 Å)