3L3U

Crystal structure of the HIV-1 integrase core domain to 1.4A

3L3U の概要

• エントリーDOI: 10.2210/pdb3l3u/pdb
• 関連するPDBエントリー: 1bl3 1ex4 3L3V
• 分子名称: POL polyprotein, SULFATE ION (3 entities in total)
• 機能のキーワード: dna integration, aids, integrase, endonuclease, polynucleotidyl transferase, dna binding, viral protein
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35892.54

構造登録者

Wielens, J.,Chalmers, D.K.,Scanlon, M.J.,Parker, M.W. (登録日: 2009-12-17, 公開日: 2010-03-31, 最終更新日: 2023-11-01)

主引用文献

Wielens, J.,Headey, S.J.,Jeevarajah, D.,Rhodes, D.I.,Deadman, J.,Chalmers, D.K.,Scanlon, M.J.,Parker, M.W.
Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site.
Febs Lett., 584:1455-1462, 2010

PubMed Abstract: HIV integrase (IN) is an essential enzyme in HIV replication and an important target for drug design. IN has been shown to interact with a number of cellular and viral proteins during the integration process. Disruption of these important interactions could provide a mechanism for allosteric inhibition of IN. We present the highest resolution crystal structure of the IN core domain to date. We also present a crystal structure of the IN core domain in complex with sucrose which is bound at the dimer interface in a region that has previously been reported to bind integrase inhibitors.

PubMed: 20227411
DOI: 10.1016/j.febslet.2010.03.016

実験手法

X-RAY DIFFRACTION (1.4 Å)