3L3L
PARP complexed with A906894
Summary for 3L3L
Entry DOI | 10.2210/pdb3l3l/pdb |
Related | 2RCW 2RD6 3GJW 3GN7 |
Descriptor | Poly [ADP-ribose] polymerase 1, 3-oxo-2-piperidin-4-yl-2,3-dihydro-1H-isoindole-4-carboxamide (3 entities in total) |
Functional Keywords | protein-inhibitor complex, adp-ribosylation, dna damage, dna repair, dna-binding, glycosyltransferase, metal-binding, nad, nucleus, phosphoprotein, transcription, transcription regulation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P09874 |
Total number of polymer chains | 1 |
Total formula weight | 39428.11 |
Authors | Park, C.H. (deposition date: 2009-12-17, release date: 2010-12-22, Last modification date: 2024-04-03) |
Primary citation | Gandhi, V.B.,Luo, Y.,Liu, X.,Shi, Y.,Klinghofer, V.,Johnson, E.F.,Park, C.,Giranda, V.L.,Penning, T.D.,Zhu, G.D. Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg.Med.Chem.Lett., 20:1023-1026, 2010 Cited by PubMed: 20045315DOI: 10.1016/j.bmcl.2009.12.042 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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