3L32

Structure of the dimerisation domain of the rabies virus phosphoprotein

3L32 の概要

• エントリーDOI: 10.2210/pdb3l32/pdb
• 分子名称: Phosphoprotein (2 entities in total)
• 機能のキーワード: antiparallel alpha-helices, viral protein, dimerisation domain, rabies virus, phosphoprotein
• 由来する生物種: Rabies virus
• 細胞内の位置: Phosphoprotein: Virion. Isoform P3: Host nucleus (By similarity). Isoform P4: Host nucleus (By similarity). Isoform P5: Host nucleus (By similarity): Q0GBY3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 10686.28

構造登録者

Ivanov, I.,Crepin, T.,Jamin, M.,Ruigrok, R.W.H. (登録日: 2009-12-16, 公開日: 2010-02-16, 最終更新日: 2024-03-20)

主引用文献

Ivanov, I.,Crepin, T.,Jamin, M.,Ruigrok, R.W.H.
Structure of the dimerisation domain of the rabies virus phosphoprotein
J.Virol., 2010

PubMed Abstract: The crystal structure of the dimerization domain of rabies virus phosphoprotein was determined. The monomer consists of two alpha-helices that make a helical hairpin held together mainly by hydrophobic interactions. The monomer has a hydrophilic and a hydrophobic face, and in the dimer two monomers pack together through their hydrophobic surfaces. This structure is very different from the dimerization domain of the vesicular stomatitis virus phosphoprotein and also from the tetramerization domain of the Sendai virus phosphoprotein, suggesting that oligomerization is conserved but not structure.

PubMed: 20089657
DOI: 10.1128/JVI.02557-09

実験手法

X-RAY DIFFRACTION (1.5 Å)