3L1C

Kinesin-14 Protein Ncd, T436S Mutant

3L1C の概要

• エントリーDOI: 10.2210/pdb3l1c/pdb
• 分子名称: Protein claret segregational, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: kinesin ncd, atp-binding, motor protein
• 由来する生物種: Drosophila melanogaster (fruit fly)
• 細胞内の位置: Cytoplasm, cytoskeleton (Probable): P20480
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 88097.83

構造登録者

Kull, F.J. (登録日: 2009-12-11, 公開日: 2010-08-18, 最終更新日: 2023-09-06)

主引用文献

Heuston, E.,Bronner, C.E.,Kull, F.J.,Endow, S.A.
A kinesin motor in a force-producing conformation.
Bmc Struct.Biol., 10:19-19, 2010

PubMed Abstract: Kinesin motors hydrolyze ATP to produce force and move along microtubules, converting chemical energy into work by a mechanism that is only poorly understood. Key transitions and intermediate states in the process are still structurally uncharacterized, and remain outstanding questions in the field. Perturbing the motor by introducing point mutations could stabilize transitional or unstable states, providing critical information about these rarer states.

PubMed: 20602775
DOI: 10.1186/1472-6807-10-19

実験手法

X-RAY DIFFRACTION (2.75 Å)