3L0J

Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand

3L0J の概要

• エントリーDOI: 10.2210/pdb3l0j/pdb
• 分子名称: Nuclear receptor ROR-gamma, Nuclear receptor coactivator 2, (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol, ... (4 entities in total)
• 機能のキーワード: ror gamma, nuclear receptors, alternative splicing, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger, acetylation, activator, phosphoprotein, polymorphism
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (Probable): P51449; Nucleus: Q15596
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29935.94

構造登録者

Martynowski, D.,Li, Y. (登録日: 2009-12-10, 公開日: 2010-03-16, 最終更新日: 2024-02-21)

• 主引用文献: Jin, L.,Martynowski, D.,Zheng, S.,Wada, T.,Xie, W.,Li, Y.; Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma.; Mol.Endocrinol., 24:923-929, 2010; PubMed: 20203100; DOI: 10.1210/me.2009-0507

実験手法

X-RAY DIFFRACTION (2.4 Å)