3KYR

Bace-1 in complex with a norstatine type inhibitor

3KYR の概要

• エントリーDOI: 10.2210/pdb3kyr/pdb
• 関連するPDBエントリー: 3DM6 3IXJ 3IXK
• 関連するBIRD辞書のPRD_ID: PRD_001038
• 分子名称: Beta-secretase 1, 3-[[(2S)-2-[[[(2S)-2-[[(2S)-2-[[(2S)-2-azanyl-3-(1H-1,2,3,4-tetrazol-5-ylcarbonylamino)propanoyl]amino]-3-methyl-butanoyl]amino]-4-methyl-pentanoyl]amino]methyl]-2-hydroxy-4-phenyl-butanoyl]amino]benzoic acid (3 entities in total)
• 機能のキーワード: bace, beta-secretase, memapsin-2, aspartyl protease, inhibitor, norstatine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P56817
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 137963.03

構造登録者

Lindberg, J.D.,Borkakoti, N.,Derbyshire, D.,Nystrom, S. (登録日: 2009-12-07, 公開日: 2010-12-29, 最終更新日: 2024-10-09)

• 主引用文献: Wangsell, F.,Nordeman, P.,Savmarker, J.,Emanuelsson, R.,Jansson, K.,Lindberg, J.,Rosenqvist, A.,Samuelsson, B.,Larhed, M.; Investigation of a-phenylnorstatine and a-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibiotrs; To be Published,

実験手法

X-RAY DIFFRACTION (2.6 Å)