3KWY

Crystal structure of RXRalpha ligand binding domain in complex with triphenyltin and a coactivator fragment

Summary for 3KWY

• Entry DOI: 10.2210/pdb3kwy/pdb
• Descriptor: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2 peptide, triphenylstannanyl, ... (5 entities in total)
• Functional Keywords: nuclear receptor transcription organotin, dna-binding, host-virus interaction, isopeptide bond, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger, activator, phosphoprotein
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P19793 Q15596
• Total number of polymer chains: 2
• Total formula weight: 29258.45

Authors

le Maire, A.,Bourguet, W. (deposition date: 2009-12-02, release date: 2010-01-19, Last modification date: 2023-09-06)

Primary citation

le Maire, A.,Bourguet, W.,Balaguer, P.
A structural view of nuclear hormone receptor: endocrine disruptor interactions.
Cell.Mol.Life Sci., 67:1219-1237, 2010

PubMed Abstract: Endocrine-disrupting chemicals (EDCs) represent a broad class of exogenous substances that cause adverse effects in the endocrine system by interfering with hormone biosynthesis, metabolism, or action. The molecular mechanisms of EDCs involve different pathways including interactions with nuclear hormone receptors (NHRs) which are primary targets of a large variety of environmental contaminants. Here, based on the crystal structures currently available in the Protein Data Bank, we review recent studies showing the many ways in which EDCs interact with NHRs and impact their signaling pathways. Like the estrogenic chemical diethylstilbestrol, some EDCs mimic the natural hormones through conserved protein-ligand contacts, while others, such as organotins, employ radically different binding mechanisms. Such structure-based knowledge, in addition to providing a better understanding of EDC activities, can be used to predict the endocrine-disrupting potential of environmental pollutants and may have applications in drug discovery.

PubMed: 20063036
DOI: 10.1007/s00018-009-0249-2

Experimental method

X-RAY DIFFRACTION (2.3 Å)