3KVX

JNK3 bound to aminopyrimidine inhibitor, SR-3562

3KVX の概要

• エントリーDOI: 10.2210/pdb3kvx/pdb
• 分子名称: Mitogen-activated protein kinase 10, N-[(2Z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1H)-ylidene]-4-(3-morpholin-4-yl-1H-1,2,4-triazol-1-yl)aniline (3 entities in total)
• 機能のキーワード: jnk3, mapk10, inhibitor, atp-binding, epilepsy, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42694.38

構造登録者

Habel, J.E.,Laughlin, J.D.,LoGrasso, P. (登録日: 2009-11-30, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Kamenecka, T.,Jiang, R.,Song, X.,Duckett, D.,Chen, W.,Ling, Y.Y.,Habel, J.,Laughlin, J.D.,Chambers, J.,Figuera-Losada, M.,Cameron, M.D.,Lin, L.,Ruiz, C.H.,Lograsso, P.V.; Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors; J.Med.Chem., 53:419-431, 2010; PubMed: 19947601; DOI: 10.1021/jm901351f

実験手法

X-RAY DIFFRACTION (2.4 Å)