3KRL

cFMS Tyrosine kinase in complex with 5-Cyano-furan-2-carboxylic acid [4-(4-methyl-piperazin-1-yl)-2-piperidin-1-yl-phenyl]-amide

3KRL の概要

• エントリーDOI: 10.2210/pdb3krl/pdb
• 関連するPDBエントリー: 3KRJ
• 分子名称: Macrophage colony-stimulating factor 1 receptor, Basic fibroblast growth factor receptor 1, 5-cyano-N-[4-(4-methylpiperazin-1-yl)-2-piperidin-1-ylphenyl]furan-2-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, chimera, atp-binding, disulfide bond, glycoprotein, immunoglobulin domain, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P07333
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38554.02

構造登録者

Schubert, C. (登録日: 2009-11-18, 公開日: 2010-12-01, 最終更新日: 2023-09-06)

• 主引用文献: Illig, C.R.,Manthey, C.L.,Wall, M.J.,Meegalla, S.K.,Chen, J.,Wilson, K.J.,Ballentine, S.K.,Desjarlais, R.L.,Schubert, C.,Crysler, C.S.,Chen, Y.,Molloy, C.J.,Chaikin, M.A.,Donatelli, R.R.,Yurkow, E.,Zhou, Z.,Player, M.R.,Tomczuk, B.E.; Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).; J.Med.Chem., 54:7860-7883, 2011; PubMed: 22039836; DOI: 10.1021/jm200900q

実験手法

X-RAY DIFFRACTION (2.4 Å)