3KN2

HCV NS3 Protease Domain with ketoamide inhibitor

3KN2 の概要

• エントリーDOI: 10.2210/pdb3kn2/pdb
• 分子名称: HCV NS3 Protease Domain, Peptide KK-NS4A-KK, ZINC ION, ... (5 entities in total)
• 機能のキーワード: hepatitis c virus, ns3 protease domain, serine protease, ketoamide inhibitor, atp-binding, capsid protein, envelope protein, helicase, host membrane, hydrolase, membrane, nucleotide-binding, rna replication, transmembrane, virion
• 由来する生物種: Hepatitis C virus subtype 1a; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 48104.27

構造登録者

Nair, L.G.,Sannigrahi, M.,Pinto, P.,Bogen, S.,Chen, K.X.,Njoroge, G.,Prongay, A. (登録日: 2009-11-11, 公開日: 2010-01-19, 最終更新日: 2021-10-13)

• 主引用文献: Nair, L.G.,Sannigrahi, M.,Bogen, S.,Pinto, P.,Chen, K.X.,Prongay, A.,Tong, X.,Cheng, K.C.,Girijavallabhan, V.,George Njoroge, F.; P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.; Bioorg.Med.Chem.Lett., 20:567-570, 2010; PubMed: 20004570; DOI: 10.1016/j.bmcl.2009.11.094

実験手法

X-RAY DIFFRACTION (2.3 Å)