3KLN

Vibrio cholerae VpsT

3KLN の概要

• エントリーDOI: 10.2210/pdb3kln/pdb
• 関連するPDBエントリー: 3KLO
• 分子名称: Transcriptional regulator, LuxR family (1 entity in total)
• 機能のキーワード: rec domain, hth domain, dna-binding, transcription, transcription regulation
• 由来する生物種: Vibrio cholerae
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 103872.01

構造登録者

Krasteva, P.V.,Navarro, V.A.S.,Sondermann, H. (登録日: 2009-11-08, 公開日: 2010-02-09, 最終更新日: 2024-02-21)

主引用文献

Krasteva, P.V.,Fong, J.C.,Shikuma, N.J.,Beyhan, S.,Navarro, M.V.,Yildiz, F.H.,Sondermann, H.
Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP.
Science, 327:866-868, 2010

PubMed Abstract: Microorganisms can switch from a planktonic, free-swimming life-style to a sessile, colonial state, called a biofilm, which confers resistance to environmental stress. Conversion between the motile and biofilm life-styles has been attributed to increased levels of the prokaryotic second messenger cyclic di-guanosine monophosphate (c-di-GMP), yet the signaling mechanisms mediating such a global switch are poorly understood. Here we show that the transcriptional regulator VpsT from Vibrio cholerae directly senses c-di-GMP to inversely control extracellular matrix production and motility, which identifies VpsT as a master regulator for biofilm formation. Rather than being regulated by phosphorylation, VpsT undergoes a change in oligomerization on c-di-GMP binding.

PubMed: 20150502
DOI: 10.1126/science.1181185

実験手法

X-RAY DIFFRACTION (3.078 Å)