3KFC

Complex Structure of LXR with an agonist

Summary for 3KFC

Entry DOI	10.2210/pdb3kfc/pdb
Descriptor	Oxysterols receptor LXR-beta, 4-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)quinoline (3 entities in total)
Functional Keywords	nuclear receptor, lxr, liver x receptor, lxr agonist, lxr ligand, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Potential): P55055
Total number of polymer chains	4
Total formula weight	117559.45
Authors	Olland, A.,Bernotas, R.C.,Unwalla, R. (deposition date: 2009-10-27, release date: 2009-12-08, Last modification date: 2024-02-21)
Primary citation	Bernotas, R.C.,Singhaus, R.R.,Kaufman, D.H.,Travins, J.M.,Ullrich, J.W.,Unwalla, R.,Quinet, E.,Evans, M.,Nambi, P.,Olland, A.,Kauppi, B.,Wilhelmsson, A.,Goos-Nilsson, A.,Wrobel, J. 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists. Bioorg.Med.Chem.Lett., 20:209-212, 2010 Cited by PubMed: 19932617 DOI: 10.1016/j.bmcl.2009.10.132 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation