3KF7

Crystal Structure of Human p38alpha Complexed With a Triazolopyrimidine compound

3KF7 の概要

• エントリーDOI: 10.2210/pdb3kf7/pdb
• 分子名称: Mitogen-activated protein kinase 14, 3-{6-[2-(2,4-difluorophenyl)ethyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}-4-methylbenzamide (3 entities in total)
• 機能のキーワード: two lobes, atp pocket, peptide flip, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41735.60

構造登録者

Shieh, H.-S.,Williams, J.M.,Stegeman, R.A.,Xing, L.,Jerome, K.D. (登録日: 2009-10-27, 公開日: 2009-12-29, 最終更新日: 2024-02-21)

• 主引用文献: Jerome, K.D.,Rucker, P.V.,Xing, L.,Shieh, H.S.,Baldus, J.E.,Selness, S.R.,Letavic, M.A.,Braganza, J.F.,McClure, K.F.; Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition.; Bioorg.Med.Chem.Lett., 20:469-473, 2010; PubMed: 19969459; DOI: 10.1016/j.bmcl.2009.11.114

実験手法

X-RAY DIFFRACTION (2 Å)