3KCZ

Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor 3-aminobenzamide

3KCZ の概要

• エントリーDOI: 10.2210/pdb3kcz/pdb
• 分子名称: Poly [ADP-ribose] polymerase 2, 3-aminobenzamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: transferase, enzyme-inhibitor complex, catalytic fragment, structural genomics, structural genomics consortium, sgc, glycosyltransferase, nad, nucleus, dna-binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q9UGN5
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84112.33

構造登録者

Karlberg, T.,Schutz, P.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kallas, A.,Kotenyova, T.,Kotzsch, A.,Kraulis, P.,Nielsen, T.K.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Roos, A.K.,Siponen, M.I.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Schuler, H.,Structural Genomics Consortium (SGC) (登録日: 2009-10-22, 公開日: 2009-11-10, 最終更新日: 2023-11-01)

• 主引用文献: Karlberg, T.,Hammarstrom, M.,Schutz, P.,Svensson, L.,Schuler, H.; Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.; Biochemistry, 49:1056-1058, 2010; PubMed: 20092359; DOI: 10.1021/bi902079y

実験手法

X-RAY DIFFRACTION (2 Å)