3KCK
A Novel Chemotype of Kinase Inhibitors
3KCK の概要
エントリーDOI | 10.2210/pdb3kck/pdb |
分子名称 | Tyrosine-protein kinase JAK2, 3-chloro-4-(4H-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol (3 entities in total) |
機能のキーワード | kinase, inhibitor, jak2, janus kinase, atp-binding, chromosomal rearrangement, disease mutation, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Endomembrane system; Peripheral membrane protein (By similarity): O60674 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 37128.59 |
構造登録者 | |
主引用文献 | Wang, T.,Ledeboer, M.W.,Duffy, J.P.,Pierce, A.C.,Zuccola, H.J.,Block, E.,Shlyakter, D.,Hogan, J.K.,Bennani, Y.L. A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors. Bioorg.Med.Chem.Lett., 20:153-156, 2010 Cited by PubMed: 19945871DOI: 10.1016/j.bmcl.2009.11.021 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
構造検証レポート
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