3KCE

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors

3KCE の概要

• エントリーDOI: 10.2210/pdb3kce/pdb
• 関連するPDBエントリー: 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI
• 分子名称: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, DODECAETHYLENE GLYCOL, 5-methyl-1H-indole-2-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: sbdd, ppiase, isomerase, rotamase, small molecule, proline directed kinase, cell cycle, oncogenic transformation, nucleus, phosphoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q13526
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19246.36

構造登録者

Baker, L.M.,Dokurno, P.,Robinson, D.A.,Surgenor, A.E.,Murray, J.B.,Potter, A.J.,Moore, J.D. (登録日: 2009-10-21, 公開日: 2009-12-22, 最終更新日: 2023-11-01)

• 主引用文献: Potter, A.J.,Ray, S.,Gueritz, L.,Nunns, C.L.,Bryant, C.J.,Scrace, S.F.,Matassova, N.,Baker, L.M.,Dokurno, P.,Robinson, D.A.,Surgenor, A.E.,Davis, B.,Murray, J.B.,Richardson, C.M.,Moore, J.D.; Structure-guided design of alpha-amino acid-derived Pin1 inhibitors; Bioorg.Med.Chem.Lett., 20:586-590, 2010; PubMed: 19969456; DOI: 10.1016/j.bmcl.2009.11.090

実験手法

X-RAY DIFFRACTION (1.9 Å)