3K99

HSP90 N-terminal domain in complex with 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol

3K99 の概要

• エントリーDOI: 10.2210/pdb3k99/pdb
• 関連するPDBエントリー: 3K97 3K98
• 分子名称: Heat shock protein HSP 90-alpha, 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol (3 entities in total)
• 機能のキーワード: hsp90, n-terminal domain, atp binding domain, inhibition, acetylation, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106668.00

構造登録者

Gajiwala, K.S.,Davies II, J.F. (登録日: 2009-10-15, 公開日: 2010-02-09, 最終更新日: 2024-02-21)

• 主引用文献: Kung, P.P.,Huang, B.,Zhang, G.,Zhou, J.Z.,Wang, J.,Digits, J.A.,Skaptason, J.,Yamazaki, S.,Neul, D.,Zientek, M.,Elleraas, J.,Mehta, P.,Yin, M.J.,Hickey, M.J.,Gajiwala, K.S.,Rodgers, C.,Davies, J.F.,Gehring, M.R.; Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.; J.Med.Chem., 53:499-503, 2010; PubMed: 19908836; DOI: 10.1021/jm901209q

実験手法

X-RAY DIFFRACTION (2.1 Å)