3K90

The Abscisic acid receptor PYR1 in complex with Abscisic Acid

3K90 の概要

• エントリーDOI: 10.2210/pdb3k90/pdb
• 分子名称: Putative uncharacterized protein, (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: gene regulator, hormone, plant protein, signaling protein, start domain, bet v i domain, hormone-receptor complex, regulator of protein phosphatase type 2c, hormone receptor, hydrolase regulator
• 由来する生物種: Arabidopsis thaliana (Mouse-ear cress)
• 細胞内の位置: Cytoplasm (By similarity): O49686
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 87686.33

構造登録者

Dupeux, F.D.,Santiago, J.,Rodriguez, P.L.,Marquez, J.A. (登録日: 2009-10-15, 公開日: 2009-11-10, 最終更新日: 2023-11-01)

主引用文献

Santiago, J.,Dupeux, F.,Round, A.,Antoni, R.,Park, S.Y.,Jamin, M.,Cutler, S.R.,Rodriguez, P.L.,Marquez, J.A.
The abscisic acid receptor PYR1 in complex with abscisic acid.
Nature, 462:665-668, 2009

PubMed Abstract: The plant hormone abscisic acid (ABA) has a central role in coordinating the adaptive response in situations of decreased water availability as well as the regulation of plant growth and development. Recently, a 14-member family of intracellular ABA receptors, named PYR/PYL/RCAR, has been identified. These proteins inhibit in an ABA-dependent manner the activity of a family of key negative regulators of the ABA signalling pathway: the group-A protein phosphatases type 2C (PP2Cs). Here we present the crystal structure of Arabidopsis thaliana PYR1, which consists of a dimer in which one of the subunits is bound to ABA. In the ligand-bound subunit, the loops surrounding the entry to the binding cavity fold over the ABA molecule, enclosing it inside, whereas in the empty subunit they form a channel leaving an open access to the cavity, indicating that conformational changes in these loops have a critical role in the stabilization of the hormone-receptor complex. By providing structural details on the ABA-binding pocket, this work paves the way for the development of new small molecules able to activate the plant stress response.

PubMed: 19898494
DOI: 10.1038/nature08591

実験手法

X-RAY DIFFRACTION (2 Å)