3K8S

Crystal Structure of PPARg in complex with T2384

3K8S の概要

• エントリーDOI: 10.2210/pdb3k8s/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 2-chloro-N-{3-chloro-4-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]phenyl}-4-(trifluoromethyl)benzenesulfonamide (3 entities in total)
• 機能のキーワード: ppargamma, ligand binding pocket, ligand, diabetic, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, lbd and ligand binding domain
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63897.83

構造登録者

Wang, Z. (登録日: 2009-10-14, 公開日: 2009-11-03, 最終更新日: 2023-09-06)

• 主引用文献: Li, Y.,Wang, Z.,Furukawa, N.,Escaron, P.,Weiszmann, J.,Lee, G.,Lindstrom, M.,Liu, J.,Liu, X.,Xu, H.,Plotnikova, O.,Prasad, V.,Walker, N.,Learned, R.M.,Chen, J.-L.; T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties; J.Biol.Chem., 283:9168-9176, 2008; PubMed: 18263587; DOI: 10.1074/jbc.M800104200

実験手法

X-RAY DIFFRACTION (2.55 Å)